Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacyArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 angiotensin-converting enzyme 2 Biomarker change changes in circulating cleaved COVID-19 death declined demonstrated Disease progression dose Efficacy elevated expressing full-length highlight host cell receptor human ACE2 humans immunization increase in K18-hACE2 mice membrane mice MVA-S vaccine prevented Proteolytic processing receptor SARS-CoV-2 SARS-COV-2 infection serum serum sample serum. subsequent susceptible the SARS-CoV-2 transgenic vaccination Vaccine vaccine candidate virus virus entry [DOI] 10.3389/fimmu.2022.1001951 PMC 바로가기
Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 VariantsArticle Published on 2022-10-012022-11-16 Journal: The protein journal [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 adopted affinity antibody biochemical characterization Degradation help host cell receptor host receptor immune response immunological IMPROVE increase in infected individual interact Intervention medical intervention mutant Mutation mutations natural selection neutralizing antibody parental protease Rapid RBD receptor Receptor binding domain responses SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sensitivity the RBD thermal stability Transmissibility understanding variant variants of concern variants. [DOI] 10.1007/s10930-022-10073-6 PMC 바로가기
A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmesSARS-CoV-2에 대한 척추동물 감수성 식별을 위한 새로운 구조 기반 접근 방식: 미래 감시 프로그램에 대한 의미Article Published on 2022-09-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity conservation contribute coronavirus Critical Cross-species transmission debatable dissociation Dissociation constant domain facilitate facilitated genetic determinant genetic determinants highlight Host host cell host cell receptor host cells host range hosts in vivo Intensive interacting residue Interaction isoform Ligand mechanism molecular interaction Outbreaks Pathogens Prevent profile Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Scientific community severe acute respiratory syndrome Coronavirus spike Spike protein Surveillance susceptibility susceptible the SARS-CoV-2 understanding Vertebrate Vertebrate species. viral evolution virus entry zoonotic pathogens [DOI] 10.1016/j.envres.2022.113303 PMC 바로가기 [Article Type] Article
Can plant-derived anti-HIV compounds be used in COVID-19 cases?Research article Published on 2022-09-012022-10-05 Journal: Medical Hypotheses [Category] 변종, 임상, 치료기술, [키워드] ACE2 angiotensin-converting enzyme 2 BASIL binding score Calanolides A Can Care caused clinical trial Combination Compound coronavirus COVID-19 COVID-19 epidemic COVID-19 pandemic Effect Effects Health HIV HIV infection Holy Basil host cell receptor Interaction Intervention investigated Kuwanon-L management nucleoside analogs pandemic Patentiflorin A people with HIV promote Protease inhibitor S protein targets these compound treat Treatment viral spike protein with HIV [DOI] 10.1016/j.mehy.2022.110926 [Article Type] Research article
SARS-CoV-2’s Variants of Concern: A Brief CharacterizationSARS-CoV-2의 우려 변종: 간략한 특성Review Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin angiotensin-2 converting enzyme B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Cell Characteristics characterization coronavirus COVID-19 COVID-19 vaccination Defense Delta Gamma Genetic Host host cell host cell receptor Immune escape immune responses immunogenic modify Mutation N-terminal new SARS-CoV-2 omicron pandemic coronavirus promote raise RBD S protein SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein variant variants variants of concern viral immune escape. virus virus transmissibility VoC VOCs [DOI] 10.3389/fimmu.2022.834098 PMC 바로가기 [Article Type] Review
An Electrostatically-steered Conformational Selection Mechanism Promotes SARS-CoV-2 Spike Protein Variation정전기로 조종되는 구조적 선택 메커니즘은 SARS-CoV-2 스파이크 단백질 변이를 촉진합니다Article Published on 2022-07-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acids Analysis analyzed collected conformational conformational change conformational changes COVID-19 COVID-19 pandemic Critical Cross-species transmission epidemiological epidemiological surveillance Evolution fusion global public health global public health emergency HADDOCK heterogeneity host cell host cell receptor hydrophobicity identify immune evasion IMPROVE local interaction local interactions MOST outbreak promote Protein protein–protein interactions protein–protein interactions. Recognition recorded reducing Region replacing risk S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Selection sequence variation spike Substitution substitutions Surveillance the S protein trimer vaccination Vaccine development variant [DOI] 10.1016/j.jmb.2022.167637 PMC 바로가기 [Article Type] Article
Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective interaction with host cell receptors번역 후 변형은 숙주 세포 수용체와의 효과적인 상호 작용을 위해 SARS-CoV-2 스파이크의 능력을 최적화합니다Article Published on 2022-07-122022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome amplify antibody Complete conformational conserved construction coronavirus Coronaviruses Critical cryo-EM diagnostics docking domain domains effective flexible functional glycosylated glycosylation heterogeneity highlighting hinge region homology host cell host cell receptor host cell surface Interaction interactions Local maintain MD simulation membrane membrane-bound Microscopy Modification molecular molecular dynamics Protein receptor recognize reduced SARS coronaviruses SARS-CoV-2 SARS-CoV-2 spike single trajectory spike glycoprotein Spike protein structural dynamics. structural flexibility therapeutic Vaccines viral envelope viral infection virulence virus while [DOI] 10.1073/pnas.2119761119 PMC 바로가기 [Article Type] Article
Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unitSARS-CoV-2 스파이크 당단백질의 자가유래 펩타이드가 동종삼량체 단위의 형태와 안정성을 방해Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] approach binding binding affinity blocker blockers conformation COVID dataset destabilized develop disrupting domain exhibited functional higher affinity homotrimer host cell host cell receptor instability linear Linear motif molecular molecular dynamics monomer motif mutated Mutation opposite peptide peptides Protein protein structure RBD Region regions responsible resulting S protein S1 and S2 S1 and S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 S Self-derived peptides shown spike spike glycoprotein stability Structural folding structure-based design subunit Support the S protein the SARS-CoV-2 Vaccine design vaccine. variant wild type β-coronavirus [DOI] 10.1016/j.biopha.2022.113190 PMC 바로가기 [Article Type] Article
Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspectiveSARS-CoV-2의 부착으로 차가버섯 테르페노이드의 간섭; 실리코 관점에서Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] 501.V2 affinities approach binding affinities binding affinity binding energy can be used cancer cell Cancer cells Chaga terpenoids compounds COVID-19 domain drug finding Glucose GRP78 host cell host cell receptor HSPA5 in silico in vivo in-silico inhibitor interfere Interference investigator MM-GBSA molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations NAMD. pandemic peptide performed Perspective Protein receptor receptors Recognition reported Result SARS-CoV-2 SARS-CoV-2 receptor targeting terpenoid tested the binding affinity the SARS-CoV-2 therapeutic variants variants of SARS-CoV-2 was tested [DOI] 10.1016/j.compbiomed.2022.105478 PMC 바로가기 [Article Type] Article